Neuropathic Pain Market Size, Share, Opportunities, And Trends By Drug Class (Tricyclic Anti-Depressant, Anticonvulsant, Local Anesthesia, Opioids, Steroids, Others), By Indication (Diabetic neuropathy, Chemotherapy-induced Peripheral neuropathy, Others), By Distribution Channel (Retail Pharmacies, Drug Store, Online Pharmacies), And By Geography - Forecasts From 2024 To 2029

The neuropathic pain market is anticipated to expand at a high CAGR over the forecast period.

Neuropathic pain, a challenging and often debilitating condition, stems from damage or dysfunction of the nerves, typically outside the brain and spinal cord. This type of pain arises due to abnormalities in the nervous system and is characterized by sensations such as shooting, burning, or electric shock-like pain. Conditions such as diabetic neuropathy, postherpetic neuralgia, and peripheral neuropathy contribute to the prevalence of neuropathic pain. Unlike nociceptive pain, which results from tissue damage, neuropathic pain can persist even after the initial injury or disease has healed. Managing neuropathic pain poses a significant medical challenge, as traditional analgesics may offer limited relief. Ongoing research and development efforts focus on innovative treatments, including non-opioid approaches, to improve the quality of life for individuals affected by neuropathic pain.

Market Drivers

• Growing incidence of diabetic neuropathy.

The market is expected to experience notable growth in the foreseeable future, attributed to the increasing prevalence of diabetic neuropathy and other targeted diseases, along with a rise in healthcare spending and research funding. According to the 2021 report from the International Diabetes Federation (IDF), there were 537 million adults aged 20 to 79 living with diabetes globally in 2021. Projections indicate a surge to 643 million by 2030 and a further increase to 783 million by 2045. This substantial burden of diseases associated with neuropathic pain underscores the demand for therapeutic interventions, thereby contributing to the market's expansion.

• Endorsement of medications by regulatory authorities.

The market experiences substantial growth due to the approval of drugs by regulatory bodies. As an illustration, in March 2022, Daiichi Sankyo Company, Limited obtained approval in Japan to modify the indication of the analgesic 'Tarlige Tablets' (pregabalin besilate) from 'peripheral neuropathic pain' to 'neuropathic pain.' These regulatory approvals broaden the accessibility of therapeutics for neuropathic pain, contributing to an accelerated market expansion.

North America is anticipated to hold a significant share of the market-

North America is anticipated to secure a significant market share due to the elevated prevalence of neuropathic diseases, increased investment in research and development, and the robust presence of key market players. According to the 2021 report from the International Diabetes Federation (IDF), the North American region had 49.3 million adults aged 20-79 with diabetes in 2021, and this number is projected to exceed 55 million by 2030. The escalating diabetes burden in the region is poised to generate growth opportunities in the market. Government grants for Peripheral Neuropathy research are anticipated to offer prospects for market players to develop effective drugs, consequently propelling market growth in the coming years. Moreover, the market growth in the region is substantially influenced by strategic measures like research and development, product launches, and collaborations undertaken by key industry players. As an illustration, in September 2021, Biogen Inc. announced favorable topline outcomes from the Phase 2 CONVEY study of vixotrigine (BIIB074), an investigative non-opioid oral pain medication targeted for the treatment of small fiber neuropathy (SFN). The increasing focus on research initiatives enhances the potential for introducing innovative drugs for neuropathic pain in the coming years, thereby expediting market growth.

Market Developments

• In March 2023, Confo Therapeutics, a company specializing in the discovery of medications targeting G-protein coupled receptors (GPCRs), unveiled a global licensing agreement with Eli Lilly and Company for Confo’s clinical stage CFTX-1554 and its backup compounds. CFTX-1554, an innovative inhibitor of the angiotensin II type 2 receptor (AT2R) presently undergoing Phase 1 clinical development, presents a non-opioid strategy for addressing neuropathic pain—a debilitating condition resulting from nerve damage outside the brain and spinal cord and is potentially applicable to other peripheral pain indications. Current treatment options often prove inadequately effective and may lead to severe side effects, including addiction. Consequently, there is an urgent demand for well-tolerated and effective analgesics that do not compromise the patients' quality of life.
• In September 2022, the commencement of a phase 2 clinical trial was announced to assess ATX01 (topical amitriptyline) for adults experiencing chemotherapy-induced peripheral neuropathy (CIPN). AlgoTx is the manufacturer overseeing this trial, which is set to take place across more than 40 centers in the United States and Europe.
• In July 2022, Novaremed AG and NeuroFront Therapeutics (Hong Kong) Limited entered into an exclusive collaboration and commercialization agreement concerning Novaremed's groundbreaking non-opioid investigational drug, NRD.E1. This drug is currently in development for treating diabetes-related neuropathic pain and other indications related to neuropathic pain. According to the terms of the agreement, NeuroFront is committed to providing Novaremed with over USD 130 million in option and exercise fees, along with payments linked to development, regulatory milestones, sales milestones, and royalties based on net sales.
• In January 2021, Eli Lilly and Company and Asahi Kasei Pharma Corporation disclosed a licensing agreement in which Lilly will obtain exclusive rights to AK1780 from Asahi Kasei Pharma. AK1780, identified as an orally bioavailable P2X7 receptor antagonist, successfully concluded Phase 1 single and multiple ascending dose studies as well as clinical pharmacology investigations. P2X7 receptors are consistently implicated in neuroinflammation, a pivotal factor in chronic pain conditions. Per the agreement terms, Lilly is set to assume responsibility for the future global development and regulatory activities for AK1780, while Asahi Kasei Pharma will retain promotional rights for AK1780 in Japan and China (including Hong Kong and Macau).

Market Segmentation

• By Drug Class
  • Tricyclic Anti-Depressant
  • Anticonvulsant
  • Local Anesthesia
  • Opioids
  • Steroids
  • Others
• By Indication
  • Diabetic neuropathy
  • Chemotherapy-induced Peripheral neuropathy
  • Others
• By Distribution Channel
  • Retail Pharmacies
  • Drug Store
  • Online Pharmacies
• By Geography
  • North America
    • USA
    • Canada
    • Mexico
  • South America
    • Brazil
    • Argentina
    • Others
  • Europe
    • UK
    • Germany
    • France
    • Italy
    • Spain
    • Others
  • Middle East and Africa
    • Saudi Arabia
    • UAE
    • Others
  • Asia Pacific
    • Japan
    • China
    • India
    • South Korea
    • Taiwan
    • Thailand
    • Indonesia
    • Others

1. INTRODUCTION

1.1. Market Overview

1.2. Market Definition

1.3. Scope of the Study

1.4. Market Segmentation

1.5. Currency

1.6. Assumptions

1.7. Base, and Forecast Years Timeline

1.8. Key Benefits to the Stakeholder

2. RESEARCH METHODOLOGY  

2.1. Research Design

2.2. Research Processes

3. EXECUTIVE SUMMARY

3.1. Key Findings

3.2. Analyst View

4. MARKET DYNAMICS

4.1. Market Drivers

4.2. Market Restraints

4.3. Porter’s Five Forces Analysis

4.3.1. Bargaining Power of Suppliers

4.3.2. Bargaining Power of Buyers

4.3.3. Threat of New Entrants

4.3.4. Threat of Substitutes

4.3.5. Competitive Rivalry in the Industry

4.4. Industry Value Chain Analysis

4.5. Analyst View

5. NEUROPATHY PAIN MARKET BY DRUG CLASS

5.1. Introduction

5.2. Tricyclic Anti-Depressant

5.2.1. Market Trends and Opportunities

5.2.2. Growth Prospects

5.3. Anticonvulsant

5.3.1. Market Trends and Opportunities

5.3.2. Growth Prospects

5.4. Local Anesthesia

5.4.1. Market Trends and Opportunities

5.4.2. Growth Prospects

5.5. Opioids

5.5.1. Market Trends and Opportunities

5.5.2. Growth Prospects

5.6. Steroids

5.6.1. Market Trends and Opportunities

5.6.2. Growth Prospects

5.7. Others

5.7.1. Market Trends and Opportunities

5.7.2. Growth Prospects

6. NEUROPATHY PAIN MARKET BY INDICATION

6.1. Introduction

6.2. Diabetic neuropathy

6.2.1. Market Trends and Opportunities

6.2.2. Growth Prospects

6.3. Chemotherapy-induced Peripheral neuropathy

6.3.1. Market Trends and Opportunities

6.3.2. Growth Prospects

6.4. Others

6.4.1. Market Trends and Opportunities

6.4.2. Growth Prospects

7. NEUROPATHY PAIN MARKET BY DISTRIBUTION CHANNEL 

7.1. Introduction

7.2. Retail Pharmacies 

7.2.1. Market Trends and Opportunities

7.2.2. Growth Prospects

7.3. Drug Store

7.3.1. Market Trends and Opportunities

7.3.2. Growth Prospects

7.4. Online Pharmacies

7.4.1. Market Trends and Opportunities

7.4.2. Growth Prospects

8. NEUROPATHY PAIN MARKET BY GEOGRAPHY

8.1. Introduction

8.2. North America

8.2.1. By Drug Class 

8.2.2. By Indication

8.2.3. By Distribution Channel

8.2.4. By Country

8.2.4.1. United States

8.2.4.1.1. Market Trends and Opportunities

8.2.4.1.2. Growth Prospects

8.2.4.2. Canada

8.2.4.2.1. Market Trends and Opportunities

8.2.4.2.2. Growth Prospects

8.2.4.3. Mexico

8.2.4.3.1. Market Trends and Opportunities

8.2.4.3.2. Growth Prospects

8.3. South America

8.3.1. By Drug Class 

8.3.2. By Indication

8.3.3. By Distribution Channel

8.3.4. By Country 

8.3.4.1. Brazil

8.3.4.1.1. Market Trends and Opportunities

8.3.4.1.2. Growth Prospects

8.3.4.2. Argentina

8.3.4.2.1. Market Trends and Opportunities

8.3.4.2.2. Growth Prospects

8.3.4.3. Others

8.3.4.3.1. Market Trends and Opportunities

8.3.4.3.2. Growth Prospects

8.4. Europe

8.4.1. By Drug Class 

8.4.2. By Indication

8.4.3. By Distribution Channel

8.4.4. By Country

8.4.4.1. United Kingdom

8.4.4.1.1. Market Trends and Opportunities

8.4.4.1.2. Growth Prospects

8.4.4.2. Germany

8.4.4.2.1. Market Trends and Opportunities

8.4.4.2.2. Growth Prospects

8.4.4.3. France

8.4.4.3.1. Market Trends and Opportunities

8.4.4.3.2. Growth Prospects

8.4.4.4. Italy

8.4.4.4.1. Market Trends and Opportunities

8.4.4.4.2. Growth Prospects

8.4.4.5. Spain

8.4.4.5.1. Market Trends and Opportunities

8.4.4.5.2. Growth Prospects

8.4.4.6. Others

8.4.4.6.1. Market Trends and Opportunities

8.4.4.6.2. Growth Prospects

8.5. Middle East and Africa

8.5.1. By Drug Class 

8.5.2. By Indication

8.5.3. By Distribution Channel

8.5.4. By Country

8.5.4.1. Saudi Arabia

8.5.4.1.1. Market Trends and Opportunities

8.5.4.1.2. Growth Prospects

8.5.4.2. UAE

8.5.4.2.1. Market Trends and Opportunities

8.5.4.2.2. Growth Prospects

8.5.4.3. Others

8.5.4.3.1. Market Trends and Opportunities

8.5.4.3.2. Growth Prospects

8.6. Asia Pacific

8.6.1. By Drug Class 

8.6.2. By Indication

8.6.3. By Distribution Channel

8.6.4. By Country

8.6.4.1. Japan

8.6.4.1.1. Market Trends and Opportunities

8.6.4.1.2. Growth Prospects

8.6.4.2. China

8.6.4.2.1. Market Trends and Opportunities

8.6.4.2.2. Growth Prospects

8.6.4.3. India

8.6.4.3.1. Market Trends and Opportunities

8.6.4.3.2. Growth Prospects

8.6.4.4. South Korea

8.6.4.4.1. Market Trends and Opportunities

8.6.4.4.2. Growth Prospects

8.6.4.5. Taiwan

8.6.4.5.1. Market Trends and Opportunities

8.6.4.5.2. Growth Prospects

8.6.4.6. Thailand

8.6.4.6.1. Market Trends and Opportunities

8.6.4.6.2. Growth Prospects

8.6.4.7. Indonesia

8.6.4.7.1. Market Trends and Opportunities

8.6.4.7.2. Growth Prospects

8.6.4.8. Others

8.6.4.8.1. Market Trends and Opportunities

8.6.4.8.2. Growth Prospects

9. COMPETITIVE ENVIRONMENT AND ANALYSIS

9.1. Major Players and Strategy Analysis

9.2. Market Share Analysis

9.3. Mergers, Acquisitions, Agreements, and Collaborations

9.4. Competitive Dashboard

10. COMPANY PROFILES

10.1. Pfizer, Inc.

10.2. Sanofi S.A.

10.3. Eily Lily and Company

10.4. GlaxoSmithKline PLC

10.5. Biogen Idec.

10.6. Bristol-Myers Squibb

10.7. Baxter Healthcare Corporation

Pfizer, Inc.

Sanofi S.A.

Eily Lily and Company

GlaxoSmithKline PLC

Biogen Idec.

Bristol-Myers Squibb

Baxter Healthcare Corporation