Dengue Vaccine Market Size, Share, Opportunities, And Trends By Vaccine Type (Live attenuated vaccines, Chimeric live attenuated vaccines, Inactivated vaccines, Subunit vaccines, Nucleic acid-based vaccines), By Product (CYT-TDV (Dengvaxia), TV003/TV005, TAK-003 (DENVax), Others), By Route of Administration (Subcutaneous, Oral, Others), By End-Users (Hospitals, Government Institutes, Non-governmental Organizations (NGOs), Others), By Distribution Channel (Hospital Pharmacy, Online Pharmacy, Retail Pharmacy), And By Geography - Forecasts From 2024 To 2029

The Dengue Vaccine Market is expected to experience steady growth in the forecast period.

Dengue is a mosquito-borne viral infection caused by the Flaviviridae family, primarily transmitted by infected Aedes mosquitoes. It is prevalent in tropical and subtropical regions and can cause a range of symptoms, from mild fever to severe conditions like Dengue hemorrhagic fever (DHF) and Dengue shock syndrome (DSS). Common symptoms include high fever, severe headaches, eye pain, joint and muscle pain, rash, and mild bleeding. In severe cases, Dengue can lead to organ damage, bleeding, and a drop in blood platelet count, which can be fatal if not managed properly. A "Dengue vaccine" is a vaccine designed to provide immunity or reduce the severity of Dengue fever. The development of a Dengue vaccine has been a significant area of research and public health interest due to its global impact.

Market Drivers

• The increasing threat of the dengue epidemic spread is anticipated to drive the dengue vaccine market growth.

The global incidence of dengue has significantly increased over the past two decades, posing a significant public health challenge. From 2000 to 2019, the World Health Organization reported a ten-fold surge in reported cases, from 500,000 to 5.2 million. In 2019, an unprecedented peak was reported across 129 countries. After a slight decline between 2020-2022 due to the COVID-19 pandemic and lower reporting rates, an upsurge in dengue cases in 2023 was observed globally, characterized by a significant increase in the number, scale, and simultaneous occurrence of multiple outbreaks, spreading into previously unaffected regions. Dengue transmission is cyclic, with large outbreaks every 3-4 years. Since 2023, ongoing transmission and an unexpected spike in cases have resulted in nearly a historic high of over five million cases and over 5000 dengue-related deaths in over 80 countries/territories and five WHO regions.

• Research and development advances are expected to upsurge the dengue vaccine market.

The dengue vaccine market is anticipated to expand as a result of advancements in adjuvants, manufacturing techniques, vaccine technology, and other areas. Persistent innovation could result in the development of safer and more effective vaccinations. For instance, In December 2022, The Butantan Institute's dengue vaccine, Butantan-DV, showed 79.6% efficacy in preventing the disease, according to a phase 3 clinical study. The study, conducted between February 2016 and July 2021, involved 16,235 volunteers aged 2 to 59 years. The incidence of laboratory-confirmed symptomatic dengue cases was observed after 28 days of vaccination until the second year of follow-up. The study will continue until all participants complete five years of follow-up in 2024. Also, In September 2020, Panacea Biotec completed the Phase I/II study of its Tetravalent recombinant chimeric Dengue candidate vaccine, DengiAll. The vaccine induced robust neutralizing antibody responses against all four Dengue virus serotypes and was found to be safe and well-tolerated with no serious adverse effects. Over 80% of participants showed a tri-valent response.

• Collaborations at the global level involving healthcare stakeholders is expected to bolster the dengue vaccine market growth.

The sharing of information, resources, and expertise is facilitated by cooperative efforts between researchers, pharmaceutical companies, governmental bodies, and international organizations. International cooperation allows access to a variety of datasets and quickens the development of a dengue vaccine. For Instance, In December 2022, Instituto Butantan and Merck announced a collaboration agreement to develop investigational dengue vaccines. Both institutions are evaluating formulations similar to the NIH TV003 formulation. Under the agreement, they shared clinical data and learnings from their respective dengue vaccine development programs. This collaboration demonstrated Merck's engagement with the global public health community in developing vaccines for tropical and subtropical diseases.

Asia Pacific is expected to grow significantly.

The Asia Pacific region could be expected to significantly contribute to the dengue vaccine market growth due to several factors. The high burden of Dengue fever in many countries, along with its associated economic and healthcare costs, makes vaccine development a priority for public health. The densely populated and rapidly urbanized region creates favorable conditions for the proliferation of Aedes mosquitoes, the primary vectors of the Dengue virus. Government initiatives, collaborations between international pharmaceutical companies, research institutions, and local organizations, and increasing awareness about the disease's impact on public health can drive demand for Dengue vaccines. These factors, combined with increasing public awareness, could drive the development and introduction of new Dengue vaccines. For instance, In December 2022, Takeda, a Japanese pharmaceutical company, started submitting regulatory submissions for a dengue vaccine candidate, TAK-003, in the EU and dengue-endemic countries. This move is attracting competition from other companies, who are focusing on developing vaccines for individuals aged four to 60, particularly in the Asia Pacific region.

Market Restraints

• Public Perception and Reluctance to Vaccinate

Hesitancy towards vaccinations can be influenced by worries about vaccine safety, especially in light of the disputes around some Dengue vaccines. Successful immunization efforts depend on raising public knowledge and confidence.

Market Developments

• November 2023- The Indian Institutes of Science Education and Research (IISER), Bhopal, is working on developing a mi-RNA-based live virus vaccine candidate against Dengue.
• October 2023- The World Health Organization’s Strategic Advisory Group of Experts (SAGE) has recommended Takeda's QDENGA (dengue tetravalent vaccine) for use in high dengue burden and transmission areas. The WHO will consider the recommendation in the coming months and update its position paper on dengue vaccines to include final guidance on QDENGA's use in public vaccination programs. The vaccine is also recommended for children aged six to 16 years, introduced one to two years before peak dengue hospitalizations.
• December 2020- Indian pharmaceutical giant Sun Pharma has partnered with the International Centre for Genetic Engineering and Biotechnology (ICGEB) to develop a safe, effective, and affordable dengue vaccine. This is their second collaboration on the mosquito-borne virus, following their first collaboration on a botanical drug, Cipa. Sun Pharma will fund and support the vaccine candidate, DSV4.

Company Products

• Dengvaxia- Sanofi Pasteur developed the Dengvaxia vaccine for protection against Dengue fever, a virus spread by mosquitoes and brought on by the Dengue virus. Dengvaxia was created to specifically target the Dengue virus's four serotypes (DEN-1, DEN-2, DEN-3, and DEN-4). All of these serotypes are targeted for immunity induction by the vaccination. DENGVAXIA is licensed for use in people ages 6 to 16 who reside in dengue-endemic areas and have a history of laboratory-confirmed dengue infection.
• Qdenga (TAK-003)- Qdenga is a dengue vaccine developed by Takeda Pharmaceutics, based on a live-attenuated dengue serotype 2 virus. It is used in the European Union for dengue prevention in individuals aged four and above, administered subcutaneously at a two-dose schedule. Qdenga has been well-tolerated and has no significant safety risks identified in the TIDES trial. It is currently available in Europe, Indonesia, Brazil, Argentina, and Thailand.

Segmentation

• By Vaccine Type
  • Live attenuated vaccines
  • Chimeric live attenuated vaccines
  • Inactivated vaccines
  • Subunit vaccines
  • Nucleic acid-based vaccines
• By Product
  • CYT-TDV (Dengvaxia)
  • TV003/TV005
  • TAK-003 (DENVax)
  • Others
• By Route of Administration
  • Subcutaneous
  • Oral
  • Others
• By End-Users
  • Hospitals
  • Government Institutes
  • Non-governmental Organizations (NGOs)
  • Others
• By Distribution Channel
  • Hospital Pharmacy
  • Online Pharmacy
  • Retail Pharmacy
• By Geography
  • North America
    • USA
    • Canada
    • Mexico
  • South America
    • Brazil
    • Argentina
    • Others
  • Europe
    • Germany
    • UK
    • France
    • Spain
    • Others
  • Middle East and Africa
    • Saudi Arabia
    • UAE
    • Others
  • Asia Pacific
    • China
    • Japan
    • South Korea
    • India
    • Indonesia
    • Others

1. INTRODUCTION

1.1. Market Overview

1.2. Market Definition

1.3. Scope of the Study

1.4. Market Segmentation

1.5. Currency

1.6. Assumptions

1.7. Base, and Forecast Years Timeline

2. RESEARCH METHODOLOGY  

2.1. Research Data

2.2. Research Process

3. EXECUTIVE SUMMARY

3.1. Research Highlights

4. MARKET DYNAMICS

4.1. Market Drivers

4.2. Market Restraints

4.3. Market Opportunities

4.4. Porter’s Five Force Analysis

4.4.1. Bargaining Power of Suppliers

4.4.2. Bargaining Power of Buyers

4.4.3. Threat of New Entrants

4.4.4. Threat of Substitutes

4.4.5. Competitive Rivalry in the Industry

4.5. Industry Value Chain Analysis

4.6. Forward Proxy

5. DENGUE VACCINE MARKET BY VACCINE TYPE

5.1. Introduction

5.2. Live attenuated vaccines

5.3. Chimeric live attenuated vaccines

5.4. Inactivated vaccines

5.5. Subunit vaccines

5.6. Nucleic acid-based vaccines

6. DENGUE VACCINE MARKET BY PRODUCT

6.1. Introduction

6.2. CYT-TDV (Dengvaxia)

6.3. TV003/TV005

6.4. TAK-003 (DENVax)

6.5. Others

7. DENGUE VACCINE MARKET BY ROUTE OF ADMINISTRATION

7.1. Introduction

7.2. Subcutaneous

7.3. Oral

7.4. Others

8. DENGUE VACCINE MARKET BY END-USERS

8.1. Introduction

8.2. Hospitals

8.3. Government Institutes

8.4. Non-governmental Organizations (NGOs)

8.5. Others

9. DENGUE VACCINE MARKET BY DISTRIBUTION CHANNEL

9.1. Introduction

9.2. Hospital Pharmacy

9.3. Online Pharmacy

9.4. Retail Pharmacy

10. DENGUE VACCINE MARKET BY GEOGRAPHY

10.1. Introduction

10.2. North America

10.2.1. USA

10.2.2. Canada

10.2.3. Mexico

10.3. South America

10.3.1.  Brazil

10.3.2. Argentina

10.3.3. Others

10.4. Europe

10.4.1. Germany

10.4.2. UK

10.4.3. France

10.4.4. Spain

10.4.5. Others

10.5. Middle East and Africa

10.5.1. Saudi Arabia

10.5.2. UAE

10.5.3. Others

10.6. Asia Pacific

10.6.1. China

10.6.2. Japan

10.6.3. South Korea

10.6.4. India

10.6.5. Indonesia

10.6.6. Others

11. COMPETITIVE ENVIRONMENT AND ANALYSIS

11.1. Major Players and Strategy Analysis

11.2. Market Share Analysis

11.3. Mergers, Acquisitions, Agreements, and Collaborations

12. COMPANY PROFILES

12.1. Sanofi Pasteur Limited

12.2. Takeda Pharmaceuticals Company Limited

12.3. Butantan Institute

12.4. National Institute of Allergy and Infectious Diseases (NIAID)

12.5. Sun Pharma Industries Ltd

12.6. Merck Co. & Inc.

12.7. Inovio Pharmaceuticals

12.8. Panacea Biotec Limited

12.9. Medigen Vaccine Biologics Corporation

Sanofi Pasteur Limited

Takeda Pharmaceuticals Company Limited

Butantan Institute

National Institute of Allergy and Infectious Diseases (NIAID)

Sun Pharma Industries Ltd

Merck Co. & Inc.

Inovio Pharmaceuticals

Panacea Biotec Limited

Medigen Vaccine Biologics Corporation